Searches gene lists for over-represented pathways in the ConsensusPathDB (CPDB). This service is provided by the Max Planck Institute for Molecular Genetics.
This tool takes a filtered data set (e.g. a list of differentially expressed genes) and goes through all the pathways in CPDB. CPDB is a database that integrates pathway and other functional interaction resources like Reactome, HumanCyc, BioCarta, Pathway Interaction Database and others. For every pathway, a hypergeometric test is calculated, and the pathways that acquire a p-value smaller than the user-specified threshold are reported. This tool works with any data containing human gene symbols or UniProt identifiers. The background size used in the p-value calculation is the number of CPDB entities annotated with the same identifers (UniProt or human gene symbols).
Output is a list of significant pathways as text file (allows sorting by columns) and as an html file (with hyperlinks to the corresponding entries in the CPDB member databases).
More information can be found at the CPDB website and in the following article:
Kamburov et al: ConsensusPathDB - a database for integrating human functional interaction networks. Nuc Acids Res 37:D623-D628 (2008)